Mycoplasma Bovis

Posted by Dr. Sara Hooge on June 10 2009 09:35

1. Emerging disease in the cattle industry.

2. Colonization of M. bovis in the calf.

3. Risk Factors

   • Mixed source calves
   • Different age groups
   • Young claves with exposure to other calves between 3 and 8 weeks of age
   • Oral treansmission during transportation by commingling
   • Presence of 1 positive animal in a group
   • Late winter and early spring
   • High moisture environment

4. Antibiotic treatment research – Dr. Ricardo Rosenbush, Iowa State

   • MIC determined by respiratory M. bovis
   • Antibiotics identified as sensitive
     • Florfenicol = Nuflor
     • Spectinomycin = Myocin
     • Tulathromycin = Draaxin
     • Oxytetracycline = LA200, Tetradure
   • Antibiotic "resistance"
     • No cell wall
     • Mutates to avoid the immune system
     • Carried within macrophages
     • Causes abscessation
     • Relapsing animals – shed to the rest of the herd

5. Holsen isolates for MIC.

   Treatment

   • Florfenicol
   • Spectinomycin
   • Enrofloxacin – legality issues

6. Prevention

   Vaccine

   • 6 Holsen isolates
   • Twelve day incubation period
   • Fourteen days to build an immune response after the second vaccination

   Draaxin?

   • Performed a on farm trial.

7. Research trial

   • NP coat
   • Calf helper